Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Disabled homolog 1 (Adapter molecule functioning in neural development)

Seq-ID:

O75553 [Homo sapiens]

Download:

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	198	ILEEDVEDPVYQYIVFEAGHE	-	15316068	LTP	1.00		-	-	0.32	-	low
Y	220	IRDPETEENIYQVPTSQKKEG	-	15316068	LTP	0.93		CRKL SH2	-	0.70	-	low
Y	232	VPTSQKKEGVYDVPKSQPVSN	-	15316068	LTP	1.00		CRKL SH2	-	0.56	-	low
S	524	SPPTPAPRQSSPSKSSASHAS	CDK_group	12077184	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.96	-	low
S	548	TDDIFEEGFESPSKSEEQEAP	CDK_group	12077184	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.94	-	low

Disabled homolog 1 (Adapter molecule functioning in neural development)

Seq-ID:

P97318 [Mus musculus]

Download:

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phospholipid binding, SH2 domain binding	intracellular	positive regulation of protein kinase activity, cerebellum structural organization, radial glia guided migration of Purkinje cell, neuron migration, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, negative regulation of cell adhesion, small GTPase mediated signal transduction, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	198	ILEEDVEDPVYQYIVFEAGHE	SRC	11279201	LTP	1.00	-	-	0.33	-	medium
Y	220	IRDPETEENIYQVPTSQKKEG	SRC	11279201	LTP	0.20	-	-	0.71	-	medium
Y	232	VPTSQKKEGVYDVPKSQPNSQ	SRC	11279201	LTP	0.97	-	-	0.72	-	medium
Y	232	VPTSQKKEGVYDVPKSQPNSQ	SRC	15062102	LTP	0.97	-	-	0.72	-	medium